Centralized exchanges are subject to a tremendous number of problems simply because they contravene one of the cardinal laws of cryptocurrency - the owner of the private key is also the owner of the asset.
The biggest exchanges like Binance, OKEx and Huobi take control of user funds and use them for market manipulation.
That is the point, however centralized exchanges also bring advantages but well. There's no prove that Binance or any of these big exchanges you mentioned doing market manipulation however that is really possible considering that they are in control of really big funds, making profit out of market manipulation could also be a one way to gain additional huge profit but wrong or inappropiate.