I have a HD5850 and have tried using cgminer and guiminer scrypt on several currencies but I have had no luck. I can't seem to get it to work.
Which currency is the best in terms of ease of setup and profitable?
Thanks!
The differences between various coin setups is negligible. Once you get cgminer setup properly, you can mine any mineable coin with just a few parameter changes. You can track coin profitability here:
http://coinchoose.com/