If the exchange is in Panama, any American who uses the site must report any accounts over $10,000 to the IRS because it's deemed a foreign offshore account.  If CryptoAve accepts US clients, they will have to abide by FATCA rules as well or eventually in the future.  Even Switzerland will be abiding by FATCA reporting requirements.

I assume CryptoAve will be requesting Know-Your-Client and Anti-Money-Laundering info from all US customers -- i.e. picture ID, proof-of-residence, etc.  If not, expect the IRS and/or US government authorities knocking on CryptoAve's door.  A regulatory headache but required.

Any beta-testers out there that can comment?