I don't know anything about opiates (don't care for addictive substances or anything that you could die from), but what LSD does is create new neurons as well as new connections between neurons (which is why some experience synesthesia under the influence).
It's pretty much what happens when you learn new things and also why it's so powerful in treating depression by breaking up bad habits (or thought patterns) through the creation of new ones.
This can go out of control if you take retarded amounts in retarded environments and situations, but responsibly (low dose, no mental issues, physically and mentally healthy, not on medication, no combination with other drugs etc.) this isn't just harmless but can also be a very useful tool
One time I used small doses to study and the results were pretty remarkable. You can go much deeper than you ever could hope to in a sober state, although it's very easy to "overdose" in the sense that you'd be too busy staring at random stuff and going off on tangents instead of focusing on your task.
That's kind of my point: LSD and such have the ability to change a lot more than mood or mere behaviors. It has the ability to literally rewire your brain at the hardware/microcode level and change who you are. I know this because I have diaries and baselines before and after from many years ago. Real change, radical change. The kind of change that can cure an alcoholic, that kind of change.
Which can be done for good, but our brains run pop up blockers and malware software for a reason: To keep crap from getting embedded in our minds. LSD goes right around that stuff, and can lay your brain open to anyone with access. That's dangerous as fuck.
5MEO-DMT is similar stuff in some ways, but doesn't seem to have the time to rewrite the hardware.
That said, I can't believe another **ERROR*** no it just turns out Bitfinex is in a pissing match with SEC.