Any reason off the top of your head why the tweak profile would be completely unresponsive? It mines the same without it and does not add a line (like in your video) "Applied Tweak Profile 5...." etc
Rig of vega 64's

{
"cryptonight_type" : "normalv4",
"intensity" : 0,
"tweak_profile" : 5,
"double_threads" : true,
}