For example id shy away from ANY and ALL soviet bloc countries such as Uzbekistan based on the current political climate and the issues we have in the US with Russia right now. I would also stay away from South America as a general rule because of the massive amounts of corruption, struggle, and strife South America seems to constantly have. The US border crisis is in no small part due to the mass exodus of people in South America trying to come up this way through Mexico.
Ex-Eastern bloc countries which joined the EU are safe to do business in. You should still hire law firm if you don't know the local language though. Russia and those countries which are Russia-aligned aren't the safest places to outsiders (and to locals often, too) when it comes to doing business. Ukraine is no longer Russia-aligned but the business climate is still a little rough around the edges.