You can invest any type of currency in gambling and the result will based on your investment if you are invested they good altcoin then then it will definitely returns to you with good profit that is the simple theory here available for you.
Only play with currency which is worthless or else you may play with best and end up in losing that in bets and thus you also miss that money making opportunity which will happen during bull run. So understand that accordingly one should play .
No betting sites would allow coins without value to be played, it would be wasteful. House wants to make money in fact they are always making money and not the players. They surely prefer BTC but then there are more coins today which has value and easy to play with like EOS and TRX which OP didn't include in the poll. Right now, my first choice is EOS. TRX has lots of gambling dapps but might not be my preferred one.