Can hardware wallets like Ledger Nano be hacked and their coins stolen?
all systems still have loopholes to be hacked including hardware wallets, but hardware wallets have a smaller hacking potential than wallet software
Actually back in the past these hardware wallet have some kind of holes that's leaked around but fortunately this problem can be sorted out by the company, mainly it's a hardware problem that can cause such serious cases however it's still a fact that a hardware wallet is a lot more harder and need so much resources to be hacked than desktop or even browser wallet like metamask.
The 2 factor authentication that was built in to the hardware wallet is enough giving the hacker a hard time not to mention the encryption, unlike for example MEW that can got the DNS easily hijacked in the past.