Here's another way of thinking of that number:

Let's say we have a trillion planet Earths. On each Earth, there are a trillion people. Each person has a trillion computers. Each computer generates a trillion keys a second. All these computers have been creating a trillion keys per second since the birth of the universe 13.7 billion years ago. 10^12 * 10^12 * 10^12 * 10^12 * 60 * 60 * 24 * 365 * 13.7 * 10^9 = 4.3*10^65. This means thay they would have so far generated approximately 0.0000000004% of all private keys.

Not quite - that's the whole point of a mnemonic phrase. If you lose your hardware wallet, provided you have you phrase written down somewhere accurately and securely, you can always recover your wallets and recover your coins.