Speaking of unexchanged...
Besides getting the pool running smoothly and having the best algorithm for mining the right coin at a given time, I imagine that the mechanics of actually exchanging alts for btc's is going to be the biggest variable in profitability. The exchange rates are so volatile, I imagine that efficiency of getting the mined alts to an exchange and trading them for btc while they are still "hot" has to be a huge issue.
Is there any way to maximize efficiency in this area that you are not already taking advantage of, @Terk? Using multiple exchanges, automating transfers and sales of alts? Or is there no way to automate this stuff and it just has to be done by hand?