Coins that are outside the top 100 have the chance to break through the top 100, so it doesn't hurt to buy it. As long as it can create profits, it is a shame to miss it, what must be done is to carefully choose it because the risk of loss is higher.
wherever there will definitely be a risk so you have to be more careful to handle it properly.
above the top 100 coins the risk will be greater even though they have the opportunity to rise and become the top 100 in CMC.
You have to choose coins that are really good and can move better, of course, among the top 20 coins.