If you're gonna be a pro trader and work with large amounts, then yes.
That would be an illogical decision. There is no hard and fast rule that a person with large amount of money should try margin trading. Rather its the opposite, because you would want to save your money from getting burnt if you care for it.
Definitely if you are big whale then this question does not arise, however for those who are hoping to monetize their own pump/dumped market manipulations should do so with a huge bag of money as backup in case things go wrong. This is not something that the average trader would be able to do so I stand against it generally.