The best way is to keep them in the long term. that is the only way to offset losses. If you continue trading in this market then you will definitely continue to lose
It will help you only if you invest in good projects, that will recover after hitting their bottoms. In contrast, if you invest in bad projects, keep holding will cause entirely losses. You might lose all your money when those coins drop to 1 satoshis, or whatever price without volume, so you will not be able to sell them.