Hmm, when I send huge transaction, I get anxious too, that's normal because one wrong character or number in adress and your lovely bitcoins are gone forever, it's not like bank where you have some chance to get transaction back so you need to be very careful but what I do is following: I copy bitcoin adress, then click on search (on browser) and when adress matches, then I copy that adress in wallet and click on send. I think it's good advice if you browse walelt adress from blockchain or browser, just copy, check if that matches and then send on that adress. After this check, I'm relaxed.