That line up looks frightening at first glance but who will help the defense? That is perfect line up for breaking scared opponents but someone like Atletico Madrid, a team which can defend and be dangerous on counter attacks would tear them apart. There is way to much finesse in that team and way too little real fighters.
That's the beauty of 4-2-3-1 IMO, despite imposing more defensive responsibilities on the team generally, 2 players in defensive midfield position would likely cover up the tracks, Busquet and De Jong would do, the only vulnerability I see is that the 3 Attacking Midfielders would have more work load as well and the striker could get isolated upfront more often than not.