If Cardano - ADA going to update to 1.6, do I need to do anything if my coins are on Bittrex?
Dennis.
No, you don't have to do that. Bittrex does the update for you. However, sometimes it may take a few days for Bittrex to make an update, and they usually (temporarily) close the deposits and withdrawals while they're updating. So it's best to move the coins to Daedalus or some other light-weight wallet; however, even if you don't do that, there's not much to worry about.