Do not care about the total supply, you should watch about the market cappitalization (it is calculated from token supply * price). For example Ethereum and Ripple has almost same market cappitalization, but Ethereum is 1000x more expensive than Ripple because Ripple circulating supply is 1000times higher than Ethereum. As you can see it is not an important information. But when you choose coins by market cap, you can find some that are undervalued. (Highly used but low market cap = potential high return).