In every Bussiness have loss and profit, cryptocurrencies do not differ from it so I think if you take proper education about cryptocurrencies then you enter in cryptocurrencies and get great success 
Despite the fact that you are educated, there still lies a risk.
Who can predict the exact price of Bitcoin after years? Who can tell what will happen in the next 6 months? Are we still getting profit after 3 months? How about 1 and a half? A week maybe? We can't tell that, that is why despite the knowledge you have, you can still lose but obviously you know what to do to lessen that losses and get back the next time.