The last time I used Etherdelta was a few months ago, and it was safe to use (just you have to access with Metamask and don't import your private keys). But the volume of trading there seems nowadays very low, and it is almost replaced by Forkdelta and many other decentralized exchanges.
I was an etherdelta user a long time ago, but been months that I haven't used it to trade so I checked the current feedback from the users here if all are still ok with that exchange. Forkdelta and others might be the replacement of their services now as most of the listed coins has no trading activity anymore. One good thing here is that your funds are safe even if they suddenly disappear without you knowing they stopped their operations.
The old problems of DEX (low liquidity) comes back to haunt Etherdelta. Add to it that ERC20 tokens are losing their charm and people are now moving to TRON and EOS among others, and we get the same problems we need to overcome. That you can't simply create liquidity out of thin air. Without organic support for the tokens, you'll just end up at Step 1 all over again when the hype dies down.