The one thing to make sure of is you don't want very large unspent outputs or you can get capped.  Otherwise it is nice to be able to move wallets and certain coins around from computer to computer without sending via blockchain and losing time.  Short of that there is also the fact that if one big wallets gets corrupted and you don't have a backup or it is also bad, you are out more coins.   As far as efficiency of staking it is about the same from what I can tell..