There are several projects that combine investment in real life with cryptocurrency. But for some reason most end up with nonsense, nothing is really promising. The type of investment is also diverse, I have seen projects related to real estate but I forget the name, there are also those related to luxury and rare cars, called Curio. Please browse if you are interested.
For charity activities, such as donations, I have read that Unicef accepts Bitcoin donations. Although this is quite controversial, Unicef sees a good opportunity from cryptocurrency if this can bring change, why not?