Ok, next question

ok USB stats on this board:
USB Chipset:
- 8 x USB 3.0/2.0 ports (4 ports on the back panel, 4 ports available through
the internal USB headers)
- 6 x USB 2.0/1.1 ports (2 ports on the back panel, 4 ports available through
the internal USB headers)
Below, Only referenced the usb headers only
Internal
Connectors
2 x USB 3.0/2.0 headers
2 x USB 2.0/1.1 headers
Not overly familiar with that board but I am curious if the ports on the back are sharing lanes. As from looking at photos of this board, you have 2 x 2.0 usb slots just above a mouse ps/2 port. And 4 x 3.0 at the ethernet port. I'd suggest mixing these ports up a bit as a test. Plug the R606 in the top 3.0 port just below your ethernet port. And then try the top 2.0 port for the newpacs. If the NP continues to not work properly. Then try the next 2.0 slot below it. Test every port in this manner while the R606 remains in the one top port.
If all that continues to create the same issues. Your next method would be to use the front ports. Since this is not in a case you will need to find a way to plug a usb header cable into one of the usb header ports on the MB. As you currently have 2 for usb 2.0 and 2 for usb 3.0. Those hopefully will run on different lanes.
Last option, pick up a raspberry pi 4, throw them into a closet and call it a day

But that's the only thing I can think of testing on your setup. I wouldn't think the motherboard should cause an issue but never can tell. That's the only thing I can think of left to test. Each lane and then get one pluged up using the header ports.
And the Intel I3 or power supply would not be an issue. I had 2 x R606, 4 x Newpacs and 2 x Moonlander 2's running on a Fx8350 on a MSI FX970 gaming motherboard (old hardware since I upgraded my main rig to a Ryzen system). They worked perfectly. I've then since moved them to a Raspberry Pi 4 since with the cpu basically at idle the Pi pulls in less than 2 watts compared to a hungry FX8350.