Did you try to restart the rig first then test it again if not work there something wrong in your rig.
*If not running correctly, please verify that either Microsoft .NET Framework 2.0 or 3.5 is installed (having only .NET Framework 4.X installed is not enough).
Yes, restarted rig few times. And the same situation on the 2nd rig, where AMD+NVIDIA cards are mixed.
.net 3.5 + 4.7 are installed, as the VC++ 2013 and 2015
Running Win10 Ent.