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I think using altcoin is more favourable as even if you lose out it will be that altcoin and not bitcoin which can grow quickly whenever some news come in as this is the king of all coins . Bought everyone has different reason to play with particular coin.
Obviously, its easier to accept a loss if you bet in altcoins, but I want to keep my balance in BTC. But for the withdrawal, it is better to use transactions in altcoins, because their cost is lower.
Gambling with altcoins has its own pros and cons as compare to the one with bitcoin. The loss of altcoin is not as big as that of bitcoin. It is not that with a smaller bet of bitcoin, the loss can be decreased. The lost bitcoin was actually the source of future profits. Keeping balance in bitcoin will benefit you ultimately. Bitcoin transactions are not too expensive, they are according to the asset rate.