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Aguero? He has a good scoring record against Arsenal AFAIK, and if City do win I'll expect the margin to be more than one goal and I'll expect Kun ti be on the score sheet.
Liverpool have a fixture againts Leicester on 27th December and two fixtures against Spurs and Man U in January. Apart from them, I don't find any major hurdles.
City at the Etihad? Chelsea, there's also always the possibility of an upset in one of the fixtures. I expect them to win the league, not just undefeated.