Talking personally, I found BNB and NEO most profitable ones so far from my portfolio. It happened to me perhaps because I was among the early investors for both of these coins and once the coins were launched, the price quickly started moving in an ascending graph which made me have high yields.

I am always in search of such coins and once you find a better working product who is going to launch their token/coin you can quickly buy that similar to BNB because such coins usually have high demand depending on their utility and it derives their price to a greater extend giving us immense profits. Also trading with BNB is giving me good profits even in the bear markets.