The biggest challenge? Probably regulations. Right now HyperDAO and other projects can operate without regulatory approval given its decentralized nature. But in order to create a regulatory structure some crypto-friendly jurisdictions will be much needed. That would probably mean that lawmakers will have to agree to formulate such regulatory framework.
Opportunities? Maybe asset tokenization? Also the opportunity to expand in those sectors where traditional (centralized) financial institutions have left out large portions of the world population…