Don't be complacent. Don't run an online casino without permits, even you are running on cryptocurrencies. Seek advice from local personalities available that are knowledgeable of the risks and pre-requisites of running one in your local state. Also, don't rush things, and make testings to make sure your casino won't be abused and bankrupted by some strategies.
I think he will need to search the permission from his local authorities about creating or running a casino online. Maybe the local authorities will not have a problem with the real casino, but the casino that he wants to build is on the internet, so I think it's beyond their jurisdiction. But I am sure that the local authorities will give an explanation about what he wants to he will get the answer before he creates his gambling site. It is better if he can get legality for his gambling site so he won't have a problem in the future.