I trade on Binance with maximum 125x leverage and recently did a couple of hundred percent gains a few times.
Quite nice.
But it needs some risk management, don't use too much of your money with cross margin.
In my opinion isolated margin mode is instant margin call. Cross margin gives some room for letting the price go against you without a margin call before going back to positive again.
I also do never use any stop losses because of stop hunting. It cries for instant position closure with a loss.
But everyone like he wants it.
I have traded on Bitmex before with 100x leverage only and my main problem was not the risk. It was getting in a position with limit orders, since it only went up $0.50 for a long time in sideways times.
With Binance I mostly do market orders, since my balance can afford such a little hit. I abandoned the "limit only for position opening"-train since I switched to Binance. Seemed way more fun in these volatile times to get in a position asap.
But for the people who like limit orders: Binance is much easier to get a position opened. Much more volatile. You can get in a limit opened position there very quick. Not as quick as a market order but still quicker than on Bitmex.
(I am ready to get flamed to death right now, go ahead.

)
By the way I come from trading times from 2013/2014 when OKex was named OKCoin and they had only 20x leverage. Kraken only had 5x. And BitMEX was the hot shit back then.
Those have been funny times I am telling you. Before I could buy on any exchange I panic bought my first Bitcoin on eBay haha. Way below $500, way below that.... I think I mined my first BTC in 2012 or 2011 or something.
Anyway getting a little off track with my text here.