He can still recover from this lost, just like AJ did.
Please don't compare this to AJ vs Ruiz fight as that was clearly an upset and in the 2nd fight AJ proven it, while this fight, both fighters have equal chance of winning based on the betting odds, so I don't agree with a trilogy here but since it's part of the contract, we have no choice but to watch it.
I'm comparing it in terms of the psychological trauma that both fighters is experiencing. AJ was clearly upset and many doubt that he can return and beat Ruiz but he did. So there's a possibility that Wilder is experiencing the same psychological trauma that AJ had prior to his rematch. But it takes a lot of mental toughness to overcome it, just saying.