We also have to believe that it is not only about losing, gamblers who are addictive also have some trouble stopping even though they are already winning big, that's the reason why most of the time they end up losing even if they have a good start.
Do you mean the problem of separation from society? This problem concerns not only gambling - many online gamers or some other games become fanatics of this activity and forget about everything else. I heard in China there were cases when players died right in the gaming clubs due to the fact that they forgot to eat/sleep.