What OS are you running on the pi? What version of the Orange Pi is it? You dont need to touch the voltage pot on the newpacs. You should be able to get 500m on stock voltage.
Orange Pi 3, Armbian Bionic 20.02.1, Sipolar USB 10 ports 60w, Arctic Cooler active fan.
I seem to be unable to even get second stick to run at 500Mhz. Always downlocks to 470-85Mhz, if I connect three one is dropping with 0 chips found. The other two seem now stable at 450Mhz.