Collected a lot of mailbox information about cryptocurrency. It's about 100K.
But I don't know much about email marketing.
I hope GUYS can give good suggestions.
How to be effective without being treated as spam.

I think not all, some promotions use email. With content that is truly responsible. The email that you send in spam is caused by the IP Address of your email server that does not have a good reputation or may have entered the spam blacklist so that the email you send will always enter the spam folder.