Collected a lot of mailbox information about cryptocurrency. It's about 100K.
But I don't know much about email marketing.
I hope GUYS can give good suggestions.
How to be effective without being treated as spam.

There is no confusion at all, because all the emails with huge amount of receipients will directly goes into the spam box of every emails.So it is nothing effective at all.I doubt that anyone still believes on email marketing strategies when people keep finding new ways to promote their projects to great audiences.