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if some tool change pubkey inside save.work, and this save work recalculate within all his record, how much time its take to find changed pubkey for same 64 bit

if you change only pubkey it will be not working, due to wildDP produced from old pubkey.
You need tame wild DP with known private key and than you can use this file agan but there will be only tame DP.
I think today about using experience and concluded that it might help, but not too much. The whole point of a kangaroo is the effect of a birthday paradox. And if we have no pairs in the working file, but only one view, then the help is not too big, I think.