You could always sell anywhere (online or physically wherever you are located), and it basically depends on which demographic market you're targeting.

Technically, you need a cryptocurrency payment gateway for your online website for example, and/or maybe you'd like to take advantage of a cryptocurrency POS mobile app gateway instead, in order to process cryptocurrency payments when buying your handmade goods.

Btw, this is an example of a cryptocurrency POS mobile app gateway, here's the link: https://play.google.com/store/apps/details?id=net.cit.il_coin&hl=en_US