First of all, you should define the term "significant." Is it 10%, 20%, 30% etc.?
Second of all, you can't create a robust formula for it because each coin has different fundamentals. Well, assumed that the coins have fundamentals, not just shitcoin without any development.
Finally, the relationship between the price change and volume is a correlation and not causation.
I was thinking this too but it might be possible to use Google trends data or similar to work out if searches for the coin spike at that time. If they do, it's more likely to have fundamentals imo but I'm not entirely sure how you'd link the two anyway other than a higher volume moves a coin up on the list of coins on a lot of exchanges.