the biggest risks of DeFi applications is,The smart contracts could be hacked.There could be a backdoor that allows someone to steal all of keys. What is the backup plan for this you have.Because we have to trust this and we need reason for that.
Regardless, a run on Compound is less likely to happen than a bank run. Bank runs usually happen because of banks financial mismanagement. And people dont know about that until its too late. Due to the transparent nature of blockchain, users would probably spot anything fishy way before any run on Compound.
Not to mention Compounds high interest rates for lenders, near-instant interest payments, absence of loan terms or penalties, and accessibility by anyone anywhere make it too good to pass up on. Especially compared to boring old banks.