Its just to modify the higher straps with the 1500mhz strap. That's what most people do. However some people update the clock settings so they don't need to use an overclocking program like MSI afterburn on every start-up and update the voltage profiles so they don't have to use WattMan to undervolt on every start up.
So besides the straps for 1600Mhz+ and the core engine/memory clocks and voltage there isn't much to change. Changing anything else can damage the GPU and you shouldn't play around with random values. These days you don't need to modify even the straps, some miners do it for you on the fly. However those don't always work, like in my case so I had to mod the straps.
Most people do that, however, there's more that can be done. Such as customizing the timings.