I've been doing a low 4-figure withdrawal (SEPA) every week for about half a year now, the most recent one hitting my bank account today. No hitches, except for that one time they wanted me to answer the "extended" KYC, but that only added one extra day to the withdrawal time.

I can see why people would like to do larger withdrawals to save on fees, but I'd generally recommend splitting them to avoid hitting certain limits ($10,000 being the most important one).