DEXs are good for occasional trades. Otherwise, the gas price will eat you up.
I found DEXs and DeFi for very useful as a concept, but I don't think that they will even come close to CEX in a matter of volume and usability.
Think the only ones to really profit during these times are the miners,,, every time I see gas go up to beyond 100 (and this time it even reached 600 gwei gas) I think of the miners happily encouraging Defi projects to just keep on launching. Happy times for them leading up to ETH 2.0!