I would root for Bitcoin, Ethereum, Stellar Lumens, Iris Network, Chainlink, Cosmos, NewsCrypto and other promising coins/tokens with real use cases, utilities and realistic roadmap. As for DeFi tokens, I don't see them grow in the long run. Maybe their demand would die down after a year or two I think because of the hype created by these projects. It's just my opinion only.
Bitcoin and ETH coins are the one for me as well which are worth for holding for the long term. Other coins will differ for me and that would generally be subjective as well. Defi for me as well are short term quick profit-making coins and if Binance exchange keep on doing well then BNB is the coin to even look out for in coming years.