Ok, some standard questions to be sure we have the same config:
Do you have your pi running at stock frequency ?
Did you add additional parameters to your modules configuration ?
What is your cmdline.txt

Mine has crashed twice with spurious interrupt errors, killing the miner and taking down the pi alltogether.
I'm running with these options : baud=115200,freq=850,chips=5,modules=1,btc=0
The pi is on a powered usb hub, I've been using these hubs for my pi's for ages and not seen any issues.
The miner is on a dedicated 12V powersupply, that allows 5A, so don't see an issue there neither.
Any suggestions are welcome.