If Btc price is expensive, so does the transaction fees.
There were numbers of gamblers who has been struggling to put Btc into the gambling website due to high transaction fees and clogged mempool. It has been greatly affecting them for missing some of the game and sports they like to bet because of the confirmation waiting time which usually takes a short while with minimal transaction fees, but It's different today when Btc is rising.

I don't see anything difficult in making profits during Btc bullrun, IMO it's still the same, the only that's changed was the value of the fractions of Btc that you're betting.