As I see you are the representative of bitcasino.io on this forum. Your casino is pretty famous, right? And you aren't new on this forum, I am right again, so, I think it wouldn't be a bad move from you to share some experience because you carry a lot of data about gamblers. From my perspective and experience, I can tell that when the price rises, users usually try to hold it instead of spending. Also, most of the times users build a strategy according to current price of bitcoin in USD. If I can do 100 bet of 0.0001 bitcoin and it worths 0.01 BTC (140 USD), then tomorrow I won't be able to bet the same amount because bitcoin's price has risen up to 20K (for example) and I have to bet lower amount cause I focus on USD. But most of the users bet lowest possible bet, so in this case, it happens like these users gamble less because they can't afford more when the price of BTC is high.
Some players shift to other cryptos like eth or ltc to continue their habit everyday. Though the USD profit may not that big I've seen some gamblers actually do that. Profit doesn't matter that much to them as long as they can gamble with the amount they can spend.