Wow, that difference in hashrate can't be explained by a not functioning memory tweak. "--mt" is only supposed to boost your hashrate by a couple of MH/s per card, there's definitely something else going on. I've seen similar reports elsewhere it's a common problem regardless of what miner is used. I'm not aware of a solution for this issue, unfortunately.
I think its this (Mem tweak was designed for 4GB?) - yeah page aimed on RX 580 but similiar behaviour Im seeing now on nVidia:
https://2miners.com/blog/how-to-mine-ethereum-and-ethereum-classic-on-4gb-gpus/
What u think?