Thats not really an issue considering that they will be playing against Newcastle. Also dont forget that Liverpool was pretty much in the same situation few weeks ago, with Salah not able to play due to covid19 and lots of injuries but Liverpool managed to pull through

If you want to spice it up a bit however you could bet on Newcastle for double chance X2, the odds is quite spicy with around 5.8 I think on average for most sites. It seems even the bookies are pretty sure that Manchester City is going to win this