It depends on what you aim to. If you came into BTC and bought it for 6500 and now it's 25k you've already got almost 4x profit. If this amount is enough for you and you don't wanna risk then you are completely able to cash out your funds. What about me I'm a crypto enthusiast and I would prefer staying keep HODLing till BTC reach the moon 
If you are already at 300% profit, then why can't you recover the capital amount by selling 1/4th of your coins? You can keep the remaining 3/4th of the holdings for the long term (may be for 3-4 years) and hope that the prices would reach somewhere in the vicinity of $100,000 or even higher. Since you have already got your capital back, there is no risk in holding these coins for the long term.