Whenever I close Cudaminer (2012-02-28), my system becomes extremely sluggish (Win 7 x64). I was going to say that it seems to be MSI Afterburner that is the culprit but that might not be true. Before running Cudaminer it doesn't take up much CPU resource but after quitting Cudaminer, it fluctuates between 10 and 99%. Beforehand it's no more than 4-6%.
Here is the CPU usage after a fresh boot. It settles very quickly and stays low:

And this is minutes after I've closed Cudaminer *and* MSI Afterburner. Lots of spiking to 99% but it doesn't appear visible in the process list from what I can see.

The CPU is a single core AMD 2.8GHz Sempron but they run perfectly well with cgminer/sgminer/vertminer and AMD cards.
Any ideas?

Whilst mining (4 card rig) responsiveness is terrible too actually (this still doesn't explain why it remains so after finishing mining). Between cudaminer, cudamanager and either MSI Afterburner or EVGA Precision X (tried both) it hogs the CPU - almost 100%.

Connecting to the sytem takes a long time (sometimes times out). Testing / tweaking settings becomes far slower. When it crashes, the only solution seems to be a system reboot (often taking a very long time as the system is unresponsive).
This doesn't happen with AMD cards/drivers/mining software and it's making the switch from those to these cards extremely difficult (I want to convert! really!). System usage on the same configuration but admittedly with 1 x 7990 (hashing far faster than 4 x 750 Ti):
