I think it is worth taking a few profits along the way.
I think it is very interesting to sell about 1-10% when you reach 1000-10000% profits.
Then you can reduce a lot of your invested capital, reducing your risks and you will fell better when the price crashes again. As you will have some capital to buy back.
That is kind of what I'm doing. That way I don't rely on emotions. I sold a bit when we passed $20k, some more when we reached $35k and I'll sell a bit when we reach $50k. That way I always remain mostly invested while I can enjoy some of the profits.